Metal-protein complex-mediated transport and delivery of Ni2+ to TCR/MHC contact sites in nickel-specific human T cell activation.

Activation Sites in Nickel - Specific Human T Cell to TCR / MHC Contact 2 + and Delivery of Ni Metal - Protein Complex - Mediated Transport

A New Type of Metal Recognition by Human T Cells: Contact Residues for Peptide-independent Bridging of T Cell Receptor and Major Histocompatibility Complex by Nickel

In spite of high frequencies of metal allergies, the structural basis for major histocompatibility complex (MHC)-restricted metal recognition is among the unanswered questions in the field of T cell activation. For the human T cell clone SE9, we have identified potential Ni contact sites in the T cell receptor (TCR) and the restricting human histocompatibility leukocyte antigen (HLA)-DR structu...

A New Type of Metal Recognition by Human T Cells

In spite of high frequencies of metal allergies, the structural basis for major histocompatibility complex (MHC)-restricted metal recognition is among the unanswered questions in the field of T cell activation. For the human T cell clone SE9, we have identified potential Ni contact sites in the T cell receptor (TCR) and the restricting human histocompatibility leukocyte antigen (HLA)-DR structu...

Immunoproteomic identification and characterization of Ni2+-regulated proteins implicates Ni2+ in the induction of monocyte cell death

Nickel allergy is the most common cause of allergic reactions worldwide, with cutaneous and systemic effects potentially affecting multiple organs. Monocytes are precursors of not only macrophages but also dendritic cells, the most potent activators of nickel hypersensitivity. Monocytes are themselves important antigen-presenting cells, capable of nickel-specific T-cell activation in vivo and i...

Absorption of copper (Cu2+) and nickel (Ni2+) from aqueous solutions by volcanic ash soil

Introduction: Natural volcanic ash soil is one of minerals whose major contents are metal oxides. In this study absorption of copper (Cu2+) and nickel (Ni2+) on natural volcanic ash soil has been investigated at 27±1c as a function of PH, metal concentration, contact time and the amount of sorbet, using batch experiments. Methods: The necessary samples of natural volcanic ashes were collected...